Latest COVID-19 Research & Evidence — 16/12/20

 

Worcestershire Health Libraries: 

Latest COVID-19 Research & Evidence — 16/12/20

 

Research

 

Title: Safety and Efficacy of the BNT162b2 mRNA [BioNTech and Pfizer] COVID-19 Vaccine

Description:  A total of 43,548 participants underwent randomization, of whom 43,448 received injections: 21,720 with BNT162b2 and 21,728 with placebo.

Available from: https://www.nejm.org/doi/pdf/10.1056/NEJMoa2034577?articleTools=true

 

Title: Pulmonary Pathology of COVID-19 Following 8 Weeks to 4 Months of Severe Disease

Description:  Described here are the pathologies seen in three patients with severe COVID-19 who underwent antemortem examination of lung tissue at least 8 weeks after initial diagnosis.

Available from: https://academic.oup.com/ajcp/advance-article-pdf/doi/.../34900034/aqaa264.pdf

 

Title: COVID-19 and blood groups: ABO antibody levels may also matter

Description: Here, the authors aimed to test the hypothesis that COVID-19 patients might have lower levels of ABO antibodies than non-infected individuals [which would suggest some degree of antibody protection].

Available from: https://www.ijidonline.com/article/S1201-9712(20)32549-2/pdf

 

Guidance

 

Title: Therapeutic drugs for SARS-CoV-2 treatment: Current state and perspective

Description: This review covers therapeutic drugs with plausible efficacy against COVID-19 —and also other notable drugs, antiviral compounds, and natural products.

Available from: https://www.sciencedirect.com/science/article/...-S156757692033695X-main.pdf

 

Title: BMJ COVID-19 guidance (Last updated 14/12/20)

Description: COVID-19 point of care guidance covering: theory, diagnosis, management, follow-up, as well as additional resources (e.g. guidelines and patient leaflets).

Available from: https://bestpractice.bmj.com/topics/en-gb/3000201

 

Expert Opinions

 

Title: Therapeutic Approach Based on Pathophysiological Staging

Description: Proposed, is a therapeutic approach based on a new disease staging. This is divided into two sections: the pharmacological treatment for the phase of viral replication… and the treatment of respiratory failure.

Available from: https://openrespiratorymedicinejournal.com/VOLUME/14/PAGE/32/PDF/

 

Title: Evaluation of current diagnostic methods for COVID-19

Description: This review provides an overview and comparison of multiple reports and commercially available kits that include molecular tests, immunoassays, and sensor-based diagnostic methods for diagnosis of COVID-19.

Available from: https://aip.scitation.org/doi/pdf/10.1063/5.0021554

 

For additional support with accessing the publications above, visit www.wkp.nhs.uk