58 Coronavirus Bulletin— 24/03/21

 

Worcestershire Health Libraries: 

58 Coronavirus Bulletin— 24/03/21

For additional support on accessing the publications below, visit www.wkp.nhs.uk

 Article— Recovering cancer screening in the pandemic: strategies and their impacts.

The coronavirus pandemic has disrupted cancer screening programmes. Kregting and colleagues' microsimulation models indicate that attempting to quickly catch up with missed screens while simultaneously restarting the ongoing programme would achieve better outcomes but require substantial increases in normal screening capacity that may not be feasible.

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Article—Pain Manifestations of COVID-19 and Their Association With Mortality: A Multicenter Prospective Observational Study.

OBJECTIVES: To determine the prevalence and breakdown of pain symptoms among patients with coronavirus disease 2019 (COVID-19) infection admitted for nonpain symptoms and the association between the presence of pain and intensive care unit (ICU) admission and death.

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Article—Vaccination and non-pharmaceutical interventions for COVID-19: a mathematical modelling study

This study estimates vaccination alone is insufficient to contain the outbreak, highlighting risks associated with early/rapid relaxation of non-pharmaceutical interventions. In their absence, most optimistic assumption leads to estimated R of 1.58 (95% CI 1.36-1.84). 

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Article—Impact of COVID-19 pandemic on utilisation of healthcare services: a systematic review

Review (81 studies) found healthcare utilisation decreased by about a third during the pandemic (median 37% reduction, comprising reductions for visits of 42%, admissions 28%, diagnostics 31% and for therapeutics 30%), with greater reductions among people with less severe illness.

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Evidence summary—Cloth Face Coverings Worn by the Public to Reduce SARS-CoV-2 Transmission

This report focuses on the effectiveness of nonmedical cloth face masks worn by the public to reduce viral transmission and on considerations for textile materials and construction that may optimally protect against viral droplets.

Click here for ERCI report

 Practice - What is my covid risk?

Article provides advice for clinicians on assessing patients risk of catching, and risk of poor outcomes from COVID-19 infection. It offers advice on reducing transmission, and other factors for modifying risks. It also helps put risk into context for patients.

Click here for practice

 Review—COVID‐19 and its cardiovascular effects

This systematic literature review indicates that cardiometabolic comorbidities are common in people who are hospitalised with a COVID‐19 infection, and cardiovascular complications are frequent.

Click here for full review

 Learning— Adapting and innovating during COVID-19

NHS Employers have collated key learning and insights based on examples of adaptation and innovation showcased by NHS trusts during the COVID-19 pandemic.

Click here for innovations

 We make every effort to ensure that the information we provide for you is the best, most appropriate and most recent available to us, but Worcestershire Health Libraries can make no warranty, express or implied, as to the accuracy of any information supplied. We take no responsibility for any action taken on the basis of this information.

 

 

57 Coronavirus Bulletin— 17/03/21

Worcestershire Health Libraries: 

57 Coronavirus Bulletin— 17/03/21

For additional support on accessing the publications below, visit www.wkp.nhs.uk

 Research—Genetic mechanisms of critical illness in COVID-19

GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK ICUs identified and replicated new genome-wide significant associations and identified potential targets for repurposing drugs. 

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 Research—Assessing risk for healthcare workers during the covid-19 pandemic

This article discusses the risk factors of older, male sex, and ethnic minority for healthcare workers and how risk assessment of the workplace, workforce, and individual, with adjustment to roles, can help reduce potential workplace hazards.

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 Research—Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study

Objective to establish whether there is any change in mortality from infection with a new variant of SARS-CoV-2, designated a variant of concern (VOC-202012/1) in December 2020, compared with circulating SARS-CoV-2 variants.

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Research—Clinical outcome of COVID-19 in patients with adult congenital heart disease.

The aim of this study was to collect clinical outcome data and to identify risk factors for a complicated course of COVID-19 in patients with ACHD

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Research— Cardiovascular Manifestations of COVID-19.

This review is intended to summarize current understanding of the CV manifestations of COVID-19 and to study the relationship between SARS-CoV-2 and CVDs and discuss possible mechanisms of action behind SARS-CoV-2 infection-induced damage to the CV system.

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 Audio Interview: The Implications of Changes in the Structural Biology of SARS-CoV-2

In this audio interview conducted on March 9, 2021, the NEJM editors are joined by structural biologist Jonathan Abraham to talk about the effect of new viral variants on the transmission of SARS-CoV-2 and on its potential to escape antibody-mediated protection.

Click here to access interview

  Resources— New COVID-19 factsheet available in 22 languages from the European Lung FoundationThe European Lung Foundation has published a new COVID-19 factsheet pulling together all the information it has produced over the past year. 

Click here to access website

 Guidance—Safeguarding adults during the COVID-19 crisis

This guide to safeguarding adults during the COVID-19 pandemic has been updated (9th March 2021) to take into account the easing of lockdown restrictions.

Click here for Social Care Institute for Excellence guidance

 We make every effort to ensure that the information we provide for you is the best, most appropriate and most recent available to us, but Worcestershire Health Libraries can make no warranty, express or implied, as to the accuracy of any information supplied. We take no responsibility for any action taken on the basis of this information.

 

56 Coronavirus Bulletin— 10/03/21

 

Worcestershire Health Libraries: 

56 Coronavirus Bulletin— 10/03/21

Research— COVID-19 vaccination in patients with diabetes mellitus: Current concepts, uncertainties and challenges

Aim of paper to summarize the available evidence on the use of COVID-19 vaccines in patients with diabetes mellitus.

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Research— SARS2 simplified scores to estimate risk of hospitalization and death among patients with COVID-19.

Study examines utility of simpler models for estimating risk of hospitalization of patients with COVID-19 and mortality of these patients based on demographic characteristics (sex, age, race, median household income based on zip code) and smoking status of 12,347 patients who tested positive.

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Research—Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK

Analysis of data from CCP-UK (n=75,463) found those with severe asthma or COPD had increased mortality rates, after adjustment for a range of comorbidities. Use of inhaled steroids ≤2 weeks of admission was associated with decreased mortality in those with asthma aged ≥50 years.

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Research—Bacterial and fungal co-infections among COVID-19 patients in intensive care unit.

Study aimed to investigate the frequency and characteristics of respiratory co-infections in COVID-19 patients in the intensive care unit (ICU).

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 Research and Analysis— Lateral flow device specificity in phase 4 (post-marketing) surveillance

New analysis showing that lateral flow tests (LFDs) have a specificity of at least 99.9% when used to test in the community, and could be as high as 99.97%.

Click here  for  documents

Guidance— Methods for the detection and identification of SARS-CoV-2 variants

This technical guidance provides guidance to laboratories, microbiology experts and relevant stakeholders in making decisions on establishing or scaling up capability and capacity to detect and identify circulating SARS-CoV-2 variants, and in making decisions on which technologies to use and for which objective.

Click here for guidance

 Guidance— COVID-19: ventilation of indoor spaces to stop the spread of coronavirus

Guidance on the ventilation of indoor spaces to stop the spread of coronavirus (COVID-19).

Click here for government guidance

 Resources—COVID-19 vaccination: British Sign Language resources

This resource contains British Sign Language (BSL) videos on COVID-19 vaccination.

Click here for resources

 Podcast—Sir Michael Marmot on COVID-19, inequality, and the future of society

Professor Sir Michael Marmot joins Jessamy and Gavin to discuss how inequality and injustice have directly contributed to poorer COVID-19 outcomes, and what has to change in society post-pandemic.

Click here for podcast

 

 We make every effort to ensure that the information we provide for you is the best, most appropriate and most recent available to us, but Worcestershire Health Libraries can make no warranty, express or implied, as to the accuracy of any information supplied. We take no responsibility for any action taken on the basis of this information.

 

 

For additional support on accessing the publications, visit www.wkp.nhs.uk

 

Worcestershire Health Libraries: 55 Coronavirus Bulletin— 03/03/21

 

55 Coronavirus Bulletin— 03/03/21

 

Research—The use of aspirin for primary prevention of cardiovascular disease is associated with a lower likelihood of COVID-19 infection.

Paper hypothesized that aspirin use for primary cardiovascular disease prevention might have a protective effect on COVID-19 susceptibility and disease duration.

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Research—Lessons from applied large-scale pooling of 133,816 SARS-CoV-2 RT-PCR tests.

Article reports an analysis of 133,816 samples collected between April-September 2020 and tested by Dorfman pooling for the presence of SARS-CoV-2

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Research—Arterial and venous thromboembolism in COVID-19: a study-level meta-analysis

This meta-analysis of 102 studies (n=64503) found patients admitted to the ICU for severe COVID-19 had a high risk of VTE. Further studies are needed to determine the specific effects of COVID-19 on the risk of thrombosis in less severe .

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Research—SARS-CoV-2 lateral flow assays for possible use in national covid-19 seroprevalence surveys (React 2): diagnostic accuracy study

Objective to evaluate the performance of new lateral flow immunoassays (LFIAs) suitable for use in a national coronavirus disease 2019 (covid-19) seroprevalence programme (real time assessment of community transmission 2—React 2).

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Government decision—Information for Healthcare Professionals on COVID-19 Vaccine AstraZeneca

Click here for government information from Medicines & Healthcare products Regulatory Agency

 

Meta-Analysis—Immunosuppression as a risk factor for COVID‐19: a meta‐analysis

AIMS: To determine whether immunosuppressed patients are at higher risk of COVID-19 to help inform the management of patients receiving immunosuppressant therapies during the pandemic.

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Meta-Analysis—Immunosuppression as a risk factor for COVID‐19: a meta‐analysis

AIMS: To determine whether immunosuppressed patients are at higher risk of COVID-19 to help inform the management of patients receiving immunosuppressant therapies during the pandemic.

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Guidelines—A living WHO guideline on drugs to prevent covid-19

What is the role of drugs in preventing covid-19?Why does this matter?

Click here for BMJ guide

 Article—The scientific and ethical feasibility of immunity passports

In a Personal View, author suggests increasing understanding of neutralising antibody response to COVID-19 might make identifying members of community at low risk of contracting & transmitting COVID-19 possible. A response to ethical arguments against the passports is also provided

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We make every effort to ensure that the information we provide for you is the best, most appropriate and most recent available to us, but Worcestershire Health Libraries can make no warranty, express or implied, as to the accuracy of any information supplied. We take no responsibility for any action taken on the basis of this information.